Altered Intestinal P-glycoprotein Expression Levels Affect Pharmacodynamics under Diabetic Condition
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چکیده
منابع مشابه
[Altered intestinal P-glycoprotein expression levels affect pharmacodynamics under diabetic condition].
P-glycoprotein (P-gp), one of the important drug-efflux pumps, is known to affect pharmacokinetics and pharmacodynamics of P-gp substrate drugs. We have previously reported that intestinal P-gp expression levels are transiently decreased in streptozotocin (STZ)-induced type 1 diabetic mouse model. Herein, we examined the analgesic effects of orally administered morphine and its pharmacokinetic ...
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PURPOSE Reactive oxygen species (ROS) have multiple physiological effects that are amount-dependent. ROS are one of the causes of intestinal ischemia-reperfusion (I/R) injury. In this study, we investigated whether the amount of ROS and the degree of intestinal I/R injury affect the expression level of P-glycoprotein (P-gp). METHODS . We used hydrogen peroxide (H2O2) as ROS in in vitro experi...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2012
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.132.161